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A study on the regenerative effect of platelet-rich plasma on experimentally induced hepatic damage in albino rats
- Source :
- Canadian journal of physiology and pharmacology. 96(6)
- Publication Year :
- 2018
-
Abstract
- Hepatic fibrosis is a worldwide health problem with significant morbidity and mortality. Currently, there is no effective therapy for hepatic fibrosis. The present study was aimed to evaluate the possible regenerative effect of platelet-rich plasma (PRP) against thioacetamide (TAA)-induced hepatic damage. Eighty albino rats were included; 40 were used for PRP preparation and 40 were randomly divided into 4 groups: group I (control group); group II (PRP control); group III (TAA-intoxicated by a dose of 200 mg/kg body mass, intraperitoneally, twice weekly for 7 weeks), and group IV (TAA intoxicated + PRP treated). Macrophage inflammatory protein-1α (MIP-1α) and cyclic adenosine monophosphate (cAMP) were immunoassayed in addition to peroxinitrite level, NADPH-quinone oxidoreductase-1 (NQO1) enzyme activity, and liver function. PRP treatment showed significant improvement in hepatic function, and decreased MIP-1α and peroxinitrite levels. Meanwhile, significant increase in NQO1 enzyme activity and cAMP level were observed. The histopathological results confirmed the laboratory results with improvement of hepatic architecture except for some inflammatory cellular infiltrates. This study shows that PRP has the ability to protect against TAA-induced liver damage, possibly by improving redox status, liver histopathological architecture, and disruption of the inflammatory and fibrotic response induced by TAA.
- Subjects :
- 0301 basic medicine
Liver Cirrhosis
Physiology
Pharmacology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Hepatic damage
Physiology (medical)
Medicine
Animals
Cyclic adenosine monophosphate
business.industry
Platelet-Rich Plasma
General Medicine
Rats
030104 developmental biology
chemistry
Liver
030220 oncology & carcinogenesis
Platelet-rich plasma
Thioacetamide
Hepatic fibrosis
business
Oxidation-Reduction
Subjects
Details
- ISSN :
- 12057541
- Volume :
- 96
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Canadian journal of physiology and pharmacology
- Accession number :
- edsair.doi.dedup.....9d58a46787617eb531ea28eb16ae7d64