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Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study
- Source :
- Environmental Health, Vol 20, Iss 1, Pp 1-12 (2021), Environmental Health, Digibug. Repositorio Institucional de la Universidad de Granada, instname, Dipòsit Digital de la UB, Universidad de Barcelona
- Publication Year :
- 2021
-
Abstract
- This work was supported by the Ministry of economy and competitiveness and the National Institute of Health: Instituto de Salud Carlos III (ISCIII). Exps: PI14/00067, PI14/01716, PI14/01880, PI14/00556. BA15/00093. FFIS-CC 2016-06 AECC "Junta provincial de Murcia". FEDER and AECC 2015. Dr. J.P. Arrebola is under contract within Ramon y Cajal program (RYC-2016-20155, Ministerio de Economia, Industria y Competitividad, Spain). The EPIC-Spain cohort was supported by the Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII), the Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology -ICO (Spain).<br />Background Bisphenol A (BPA) is an endocrine disruptor that it is present in numerous products of daily use. The aim of this study was to assess the potential association of serum BPA concentrations and the risk of incident breast and prostate cancer in a sub-cohort of the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC). Methods We designed a case-cohort study within the EPIC-Spain cohort. Study population consisted on 4812 participants from 4 EPIC-Spain centers (547 breast cancer cases, 575 prostate cancer cases and 3690 sub-cohort participants). BPA exposure was assessed by means of chemical analyses of serum samples collected at recruitment. Borgan II weighted Cox regression was used to estimate hazard ratios. Results Median follow-up time in our study was 16.9 years. BPA geometric mean serum values of cases and sub-cohort were 1.12 ng/ml vs 1.10 ng/ml respectively for breast cancer and 1.33 ng/ml vs 1.29 ng/ml respectively for prostate cancer. When categorizing BPA into tertiles, a 40% increase in risk of prostate cancer for tertile 1 (p = 0.022), 37% increase for tertile 2 (p = 0.034) and 31% increase for tertile 3 (p = 0.072) was observed with respect to values bellow the limit of detection. No significant association was observed between BPA levels and breast cancer risk. Conclusions We found a similar percentage of detection of BPA among cases and sub-cohort from our population, and no association with breast cancer risk was observed. However, we found a higher risk of prostate cancer for the increase in serum BPA levels. Further investigation is needed to understand the influence of BPA in prostate cancer risk.<br />Ministry of economy and competitiveness<br />National Institute of Health: Instituto de Salud Carlos III (ISCIII)<br />AECC "Junta provincial de Murcia" PI14/00067- PI14/01716- PI14/01880- PI14/00556- BA15/00093- FFIS-CC 2016-06<br />Spanish Government RYC-2016-20155<br />Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII)<br />Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra<br />Catalan Institute of Oncology -ICO (Spain)
- Subjects :
- Oncology
Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants [Medical Subject Headings]
Male
Neoplasias de la próstata
Health, Toxicology and Mutagenesis
Endocrine Disruptors
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Cohort Studies
Prostate cancer
Breast cancer
Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Acrylates::Methacrylates::Bisphenol A-Glycidyl Methacrylate [Medical Subject Headings]
Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]
education.field_of_study
Factors de risc en les malalties
Hazard ratio
Middle Aged
European Prospective Investigation into Cancer and Nutrition
Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure [Medical Subject Headings]
Environmental pollutants
Diseases::Male Urogenital Diseases::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms [Medical Subject Headings]
Bisphenol a
Endocrine disruptor
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk [Medical Subject Headings]
Neoplasias de la mama
Population study
Female
Public aspects of medicine
RA1-1270
Disruptores endocrinos
Adult
Risk
medicine.medical_specialty
endocrine system
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]
Risk factors in diseases
Population
Estudios de cohortes
Case-cohort
Check Tags::Male [Medical Subject Headings]
Breast Neoplasms
Càncer de mama
Phenols
Bisfenol A glicidil metacrilato
Internal medicine
Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols [Medical Subject Headings]
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]
medicine
Humans
Benzhydryl Compounds
education
Persons::Persons::Age Groups::Adult [Medical Subject Headings]
Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings]
Aged
Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]
Càncer de pròstata
Proportional hazards model
business.industry
urogenital system
Research
Public Health, Environmental and Occupational Health
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Endocrine Disruptors [Medical Subject Headings]
Prostatic Neoplasms
Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]
Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Benzhydryl Compounds [Medical Subject Headings]
Environmental Exposure
medicine.disease
Industrial medicine. Industrial hygiene
RC963-969
Check Tags::Female [Medical Subject Headings]
Spain
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings]
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::Limit of Detection [Medical Subject Headings]
business
Contaminantes ambientales
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Environmental Health, Vol 20, Iss 1, Pp 1-12 (2021), Environmental Health, Digibug. Repositorio Institucional de la Universidad de Granada, instname, Dipòsit Digital de la UB, Universidad de Barcelona
- Accession number :
- edsair.doi.dedup.....9d586bbf6b5632116699e7e77714df31