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Congener-specific effects of PCBs on contractions of pregnant rat uteri
- Source :
- Reproductive toxicology (Elmsford, N.Y.). 10(1)
- Publication Year :
- 1996
-
Abstract
- Both increased and decreased gestation lengths have been reported following exposures to polychlorinated biphenyl (PCB) mixtures and congeners. Because oscillatory uterine contractions are essential for parturition, we hypothesized that the disparate findings on gestation length may be the result of distinct PCB congener-specific actions on oscillatory uterine contractions. This study examined the acute effects of PCB congeners on isometric contractions of isolated pregnant uteri and the structure-activity relationship for individual congeners. After cumulative exposure to individual PCB congeners (0.5 μM to 150 μM), oscillatory contractions were: 1) not altered by 2,4,5,2′,4′,5′-hexachlorobiphenyl, 3,4,5,3′,4′-pentachlorobiphenyl, or 3,4,3′,4′-tetrachlorobiphenyl; 2) significantly inhibited by 4-hydroxy-2′,4′,6′-trichlorobiphenyl; and 3) markedly increased by 2,4,6-trichlorobiphenyl and 2,4,2′,4′-tetrachlorobiphenyl, when compared to solvent controls. The uteri were more sensitive to PCB congeners with ortho -substituted light chlorination than those highly chlorinated, or those interacting with the Ah-receptor.
- Subjects :
- medicine.medical_specialty
Uterus
Isometric exercise
Biology
In Vitro Techniques
Toxicology
Uterine contraction
Rats, Sprague-Dawley
chemistry.chemical_compound
Structure-Activity Relationship
Uterine Contraction
Pregnancy
Internal medicine
Isometric Contraction
medicine
Animals
Analysis of Variance
Dose-Response Relationship, Drug
Polychlorinated biphenyl
Polychlorinated Biphenyls
Rats
Endocrinology
medicine.anatomical_structure
chemistry
In utero
Toxicity
Gestation
Pregnancy, Animal
Female
medicine.symptom
Muscle contraction
Subjects
Details
- ISSN :
- 08906238
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Accession number :
- edsair.doi.dedup.....9d4053eaa1f7c6689b37a963a9fcd7d7