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Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists
- Source :
- Bioorganicmedicinal chemistry letters. 8(5)
- Publication Year :
- 1999
-
Abstract
- The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics.
- Subjects :
- Fibrinogen receptor
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Platelet Glycoprotein GPIIb-IIIa Complex
In Vitro Techniques
Fibrinogen
Biochemistry
Chemical synthesis
Structure-Activity Relationship
Drug Discovery
medicine
Humans
Molecular Biology
Bicyclic molecule
Chemistry
Organic Chemistry
Biological activity
In vitro
Glycoprotein IIb/IIIa inhibitors
Quinazolines
Molecular Medicine
Platelet aggregation inhibitor
Platelet Aggregation Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....9d34e68fa88e1f133cca3c18e3ca6dd1