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Immunogenicity of a locally produced hepatitis B vaccine with the birth dose stored outside the cold chain in rural Vietnam
- Source :
- The American journal of tropical medicine and hygiene. 74(2)
- Publication Year :
- 2006
-
Abstract
- The heat stability of hepatitis B vaccine (HepB vaccine) should enable its storage outside the cold chain (OCC), increasing access to the birth dose in areas lacking refrigeration. We compared the immunogenicity of a locally produced vaccine among infants who received three doses stored within the cold chain (n = 358) or for whom the first dose was stored OCC for up to one month (n = 748). Serum was collected from these infants at age 9-18 months. The vaccine was protective in 80.3% of all infants. There were no differences in the prevalence of a protective level of antibody or antibody titer among groups of infants according to storage strategy. Differences in antibody titer between certain groups of infants could be explained by different vaccination schedules. Where birth dose coverage will be improved, HepB vaccine can be taken OCC for up to one month without affecting its immunogenicity.
- Subjects :
- Male
Rural Population
Hepatitis B virus
Hepatitis B vaccine
Birth dose
Drug Storage
Refrigeration
Virology
Medicine
Humans
Hepatitis B Vaccines
Cold chain
Hepatitis B Antibodies
Immunization Schedule
biology
business.industry
Immunogenicity
Antibody titer
Infant
Hepatitis B
Vaccination
Cold Temperature
Infectious Diseases
Treatment Outcome
Vietnam
Immunology
biology.protein
Parasitology
Female
Viral disease
Antibody
business
Subjects
Details
- ISSN :
- 00029637
- Volume :
- 74
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The American journal of tropical medicine and hygiene
- Accession number :
- edsair.doi.dedup.....9d2532f38b229f2a334a60cf8e377efa