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High pro-neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow-up
- Source :
- Acta Diabetologica
- Publication Year :
- 2021
-
Abstract
- Aims Neurotensin (NT) is a gut hormone that promotes lipids absorption and controls appetite. Elevated circulating pro-NT, the stable precursor of NT, is associated with cardiovascular (CV) disease, metabolic syndrome (MS) and type 2 diabetes (T2D). Features of MS and insulin resistance are reported also in type 1 diabetes (T1D), with detrimental impact on the overall CV risk profile. Aims of the study were to evaluate plasma pro-NT in T1D patients and to test whether its levels are associated with and/or predictive of CV risk factors and overall risk profile. Methods For this longitudinal retrospective study, we analyzed clinical data from 41 T1D individuals referring to the diabetes outpatient clinics at Sapienza University of Rome, Italy, collected at the baseline and after 10 years. Fasting plasma pro-NT levels were measured in T1D subjects at the baseline and in 34 age-, sex-, BMI-comparable healthy individuals recruited in the same period. Results Pro-NT did not differ significantly between patients and controls (median[range] pro-NT: 156.3 [96.6–198.2] vs. 179.4 [139.7–230.7] pmol/L, p = 0.26). In T1D, greater fasting pro-NT associated with poor glycemic control at baseline and predicted increased waist circumference, reduced insulin sensitivity, dyslipidemia and hypertension at 10-year follow-up. High pro-NT predicted 10-year very-high CV risk with adjusted OR = 11 (95%C.I.: 1.4–94.5; p = 0.029). Conclusions In T1D individuals, elevated pro-NT levels predict the development of adverse metabolic profile, which translates in higher CV risk profile at 10-year follow-up. Pro-NT represents a novel predictor/marker of CV risk factors in adults with T1D.
- Subjects :
- Adult
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
Biomarkers
Cardiovascular disease
Gastrointestinal peptides
Neuropeptides
Neurotensin
Type 1 diabetes
Endocrinology
Insulin resistance
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Outpatient clinic
Humans
Retrospective Studies
business.industry
Retrospective cohort study
General Medicine
medicine.disease
Peptide Fragments
Diabetes Mellitus, Type 1
Cardiovascular Diseases
Heart Disease Risk Factors
Original Article
Metabolic syndrome
business
Dyslipidemia
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Acta Diabetologica
- Accession number :
- edsair.doi.dedup.....9d20a5648228d042d63eec1e36ed3a1b