Strand separation in negatively supercoiled DNA

Authors :: Christian Mazza
Source :: Journal of Mathematical Biology, Vol. 51, No 2 (2005) pp. 198-216
Publication Year :: 2005
Publisher :: Springer Science and Business Media LLC, 2005.
Abstract: We consider a model for strand separation in negatively supercoiled dna, and study the effect of supercoiling on the localization of denaturation, using notions from statistical mechanics. The model is based on on mean field Ising system, coupled with a random field one dimensional ISing model. The effect of the word in AT and Gc associated with the DNA on localization of denaturation is studied under the hypothesis of small perimeter.<br />20 pages