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Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome
- Source :
- Gastroenterology, 142(2), 241-247. W B SAUNDERS CO-ELSEVIER INC, Gastroenterology, 142, 2, pp. 241-7, Gastroenterology, 142(2), 241-247, Gastroenterology 142 (2012) 2, Gastroenterology, 142, 241-7
- Publication Year :
- 2012
-
Abstract
- Item does not contain fulltext BACKGROUND & AIMS: Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investigated whether modifiable lifestyle factors, such as smoking and alcohol intake, increase this risk. METHODS: Using data from the GeoLynch cohort study, a prospective analysis of 386 subjects with Lynch syndrome, we calculated hazard ratios for the association between smoking and alcohol intake and development of colorectal adenoma. We used robust variance estimates in the calculation of 95% confidence intervals to account for dependency within families and adjusted for confounding by age, sex, smoking (in the analyses of alcohol intake), number of colonoscopies during the follow-up, colonic resection, and body mass index. RESULTS: During a median follow-up of 10 months, 58 subjects developed a histologically confirmed colorectal adenoma. The hazard ratio for current smokers was 6.13 (95% confidence interval, 2.84-13.22) and for former smokers was 3.03 (95% confidence interval, 1.49-6.16) compared with never smokers. Among ever smokers, a higher number of pack-years was associated with an increased risk for colorectal adenoma (P for trend = .03). There was a trend of alcohol intake increasing the risk of colorectal adenomas, although this was not statistically significant; the hazard ratio for the highest tertile of intake (median, 22 g/day) vs the lowest tertile (median, 0.4 g/day) was 1.56 (95% confidence interval, 0.71-3.43). CONCLUSIONS: Among people with Lynch syndrome, current smokers have an increased risk of colorectal adenomas. Former smokers have a lower risk than current smokers, but greater risk than never smokers. Individuals with Lynch syndrome should be encouraged to avoid smoking. 01 februari 2012
- Subjects :
- Male
Nutrition and Disease
carcinoma
Cox Regression
Risk Factors
Voeding en Ziekte
Prospective Studies
Colon Cancer
Smoking
Hazard ratio
Gastroenterology
Middle Aged
families
Lynch syndrome
hypermethylation
Female
Colorectal Neoplasms
Cohort study
metaanalysis
Adenoma
medicine.medical_specialty
Alcohol Drinking
Colorectal adenoma
Lower risk
Genetic
Translational research [ONCOL 3]
Internal medicine
medicine
cancer-risk
Humans
gene
Proportional Hazards Models
Molecular epidemiology Aetiology, screening and detection [NCEBP 1]
VLAG
Gynecology
Hepatology
Proportional hazards model
business.industry
cigarette-smoking
Hereditary Nonpolyposis Colorectal Cancer
medicine.disease
mutations
Colorectal Neoplasms, Hereditary Nonpolyposis
Confidence interval
lung-cancer
microsatellite instability
Self Report
business
Body mass index
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 00165085
- Volume :
- 142
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Gastroenterology
- Accession number :
- edsair.doi.dedup.....9d1687c11894f6054c4dde0f9df60602