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Crystal structure of the Neisseria gonorrhoeae MtrD inner membrane multidrug efflux pump
- Source :
- PLoS ONE, Vol 9, Iss 6, p e97903 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains, which are growing at an alarming rate. The MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps.
- Subjects :
- Models, Molecular
Protein Conformation
Molecular Sequence Data
Biophysics
lcsh:Medicine
Human pathogen
Crystallography, X-Ray
Global Health
medicine.disease_cause
Biochemistry
Microbiology
Antibiotic resistance
Bacterial Proteins
Medicine and Health Sciences
medicine
Outer membrane efflux proteins
Inner membrane
Public and Occupational Health
Amino Acid Sequence
lcsh:Science
Binding Sites
Multidisciplinary
biology
Membrane transport protein
lcsh:R
Membrane Proteins
Membrane Transport Proteins
Biology and Life Sciences
Neisseria gonorrhoeae
3. Good health
Infectious Diseases
Membrane protein
biology.protein
lcsh:Q
Efflux
Sequence Alignment
Protein Binding
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....9d0e7c69f02ee2d2348d4816a8a87e8c