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Surprises from Intravital Imaging of the Innate Immune Response

Authors :
Michael Mihlan
Shima Safaiyan
Manuel Stecher
Neil Paterson
Tim Lämmermann
Source :
Annual Review of Cell and Developmental Biology
Publication Year :
2022

Abstract

Successful immune responses depend on the spatiotemporal coordination of immune cell migration, interactions, and effector functions in lymphoid and parenchymal tissues. Real-time intravital microscopy has revolutionized our understanding of the dynamic behavior of many immune cell types in the living tissues of several species. Observing immune cells in their native environment has revealed many unanticipated facets of their biology, which were not expected from experiments outside a living organism. Here we highlight both classic and more recent examples of surprising discoveries that critically relied on the use of live in vivo imaging. In particular, we focus on five major cell types of the innate immune response (macrophages, microglia, neutrophils, dendritic cells, and mast cells), and how studying their dynamics in mouse tissues has helped us advance our current knowledge of immune cell–mediated tissue homeostasis, host defense, and inflammation.

Details

Language :
English
Database :
OpenAIRE
Journal :
Annual Review of Cell and Developmental Biology
Accession number :
edsair.doi.dedup.....9d051209ee8c3edf3d5b38d6b26f83f9