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Triclosan and bisphenol a affect decidualization of human endometrial stromal cells
- Source :
- Molecular and cellular endocrinology, 422 (2016): 74–83. doi:10.1016/j.mce.2015.11.017, info:cnr-pdr/source/autori:Forte, Maurizio; Mita, Luigi; Cobellis, Luigi; Merafina, Verdiana; Specchio, Raffaella; Rossi, Sergio; Mita, Damiano Gustavo; Mosca, Lavinia; Castaldi, Maria Antonietta; De Falco, Maria; Laforgia, Vincenza; Crispi, Stefania/titolo:Triclosan and bisphenol a affect decidualization of human endometrial stromal cells./doi:10.1016%2Fj.mce.2015.11.017/rivista:Molecular and cellular endocrinology (Print)/anno:2016/pagina_da:74/pagina_a:83/intervallo_pagine:74–83/volume:422
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- In recent years, impaired fertility and endometrium related diseases are increased. Many evidences suggest that environmental pollution might be considered a risk factor for endometrial physiopathology. Among environmental pollutants, endocrine disrupting chemicals (EDCs) act on endocrine system, causing hormonal imbalance which, in turn, leads to female and male reproductive dysfunctions. In this work, we studied the effects of triclosan (TCL) and bisphenol A (BPA), two widespread EDCs, on human endometrial stromal cells (ESCs), derived from endometrial biopsies from woman not affected by endometriosis. Cell proliferation, cell cycle, migration and decidualization mechanisms were investigated. Treatments have been performed with both the EDCs separately or in presence and in absence of progesterone used as decidualization stimulus. Both TCL and BPA did not affect cell proliferation, but they arrested ESCs at G2/M phase of cell cycle enhancing cell migration. TCL and BPA also increased gene expression and protein levels of some decidualization markers, such as insulin growth factor binding protein 1 (IGFBP1) and prolactin (PRL), amplifying the effect of progesterone alone. All together, our data strongly suggest that TCL and BPA might alter human endometrium physiology so affecting fertility and pregnancy outcome.
- Subjects :
- Adult
0301 basic medicine
endocrine system
medicine.medical_specialty
Stromal cell
Endocrine disrupting chemical
Environmental pollution
Endocrine Disruptors
Biology
Endometrium
Biochemistry
03 medical and health sciences
Bisphenol A
0302 clinical medicine
Endocrinology
Cell Movement
Internal medicine
Decidua
medicine
Humans
Endocrine system
IGFBP1
Endocrine disrupting chemicals
Endocrine Disruptor
Molecular Biology
Cells, Cultured
Progesterone
Cell Proliferation
030219 obstetrics & reproductive medicine
urogenital system
Cell growth
Stromal Cell
Cell Cycle
Decidualization
Middle Aged
Cell cycle
Triclosan
Prolactin
Up-Regulation
Insulin-Like Growth Factor Binding Protein 1
030104 developmental biology
medicine.anatomical_structure
Female
Stromal Cells
Human
Subjects
Details
- ISSN :
- 03037207
- Volume :
- 422
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Endocrinology
- Accession number :
- edsair.doi.dedup.....9cf7ed778432a0defa05d6ae0813453b