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Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle
- Source :
- Proceedings of the National Academy of Sciences. 100:7443-7448
- Publication Year :
- 2003
- Publisher :
- Proceedings of the National Academy of Sciences, 2003.
-
Abstract
- Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama ( Bos taurus ) and trypanosusceptible improved Kenya Boran ( Bos indicus ) cattle. Sixteen phenotypic traits were defined describing anemia, body weight, and parasitemia. One hundred seventy-seven F 2 animals and their parents and grandparents were genotyped at 477 molecular marker loci covering all 29 cattle autosomes. Total genome coverage was 82%. Putative QTL were mapped to 18 autosomes at a genomewise false discovery rate of 2 cross between N'Dama and Boran cattle could produce a synthetic breed with higher trypanotolerance levels than currently exist in the parental breeds.
- Subjects :
- Male
N'Dama
Genotype
Quantitative Trait Loci
Quantitative trait locus
Biology
Trypanosomiasis
Animals
Genetic Predisposition to Disease
Allele
Boran cattle
Crosses, Genetic
Genetics
Genome
Multidisciplinary
Autosome
Models, Genetic
Body Weight
food and beverages
Anemia
Sequence Analysis, DNA
Phenotypic trait
Biological Sciences
biology.organism_classification
Breed
Phenotype
Trait
Cattle
Female
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....9cf1944148acf2e42373496f2a9efec8