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Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats
- Source :
- Journal of Diabetes Research, Vol 2016 (2016), Sha, H, Zhao, D, Tong, X, Gregersen, H & Zhao, J 2016, ' Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats ', Journal of Diabetes Research, vol. 2016, 1826281 . https://doi.org/10.1155/2016/1826281, Journal of Diabetes Research
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage once daily for 60 days. The remodeling parameters were obtained from diabetic (DM), CRT treated diabetic (T1, 50 g/kg; T2, 25 g/kg), and normal (Con) rats. Expressions of advanced glycation end product (AGE), AGE receptor, transforming growth factor-β1 (TGF-β1), and TGF-β1 receptor in the colon wall were immunochemically detected and quantitatively analyzed. The association between the expressions of those proteins and the remodeling parameters was analyzed. The expressions of those proteins were significantly higher in different colon layers in the DM group (P<0.05,P<0.01) and highly correlated to the remodeling parameters. Furthermore, the expressions of those proteins were significantly decreased in the T1 group (P<0.05,P<0.01) but not in the T2 group (P>0.05). The corrective effect on the expressions of those proteins is likely to be one molecular pathway for the improvement of CRT on the diabetes-induced colon remodeling.
- Subjects :
- Blood Glucose
Glycation End Products, Advanced
Male
medicine.medical_specialty
AGE Receptor
Article Subject
Colon
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Receptor for Advanced Glycation End Products
Receptor, Transforming Growth Factor-beta Type I
030209 endocrinology & metabolism
Protein Serine-Threonine Kinases
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Streptozocin
Diabetes Mellitus, Experimental
Diabetes Complications
Rats, Sprague-Dawley
Transforming Growth Factor beta1
Colonic Diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Diabetes mellitus
Internal medicine
medicine
Animals
Hypoglycemic Agents
Receptor
lcsh:RC648-665
business.industry
Stomach
medicine.disease
Streptozotocin
Gastric lavage
medicine.anatomical_structure
chemistry
Experimental pathology
Advanced glycation end-product
030211 gastroenterology & hepatology
business
Receptors, Transforming Growth Factor beta
Research Article
Drugs, Chinese Herbal
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 23146753 and 23146745
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Research
- Accession number :
- edsair.doi.dedup.....9cef14e43019573b7ad8d0314218bb2e