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Market implementation of the MVA platform for pre-pandemic and pandemic influenza vaccines: A quantitative key opinion leader analysis
- Source :
- Vaccine, Ramezanpour, B, Pronker, E S, Kreijtz, J H C M, Osterhaus, A D M E & Claassen, E 2015, ' Market implementation of the MVA platform for pre-pandemic and pandemic influenza vaccines: A quantitative key opinion leader analysis. ', Vaccine, vol. 33, no. 35, pp. 3349-3358 . https://doi.org/10.1016/j.vaccine.2015.04.086, Vaccine, 33(35), 3349-3358. Elsevier BV, Vaccine, 33(35), 4349-4358. Elsevier
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- A quantitative method is presented to rank strengths, weaknesses, opportunities, and threats (SWOT) of modified vaccinia virus Ankara (MVA) as a platform for pre-pandemic and pandemic influenza vaccines. Analytic hierarchy process (AHP) was applied to achieve pairwise comparisons among SWOT factors in order to prioritize them. Key opinion leaders (KOLs) in the influenza vaccine field were interviewed to collect a unique dataset to evaluate the market potential of this platform. The purpose of this study, to evaluate commercial potential of the MVA platform for the development of novel generation pandemic influenza vaccines, is accomplished by using a SWOT and AHP combined analytic method. Application of the SWOT AHP model indicates that its strengths are considered more important by KOLs than its weaknesses, opportunities, and threats. Particularly, the inherent immunogenicity capability of MVA without the requirement of an adjuvant is the most important factor to increase commercial attractiveness of this platform. Concerns regarding vector vaccines and anti-vector immunity are considered its most important weakness, which might lower public health value of this.platform. Furthermore, evaluation of the results of this study emphasizes equally important role that threats and opportunities of this platform play. This study further highlights unmet needs in the influenza vaccine market, which could be addressed by the implementation of the MVA platform. Broad use of MVA in clinical trials shows great promise for this vector as vaccine platform for pre-pandemic and pandemic influenza and threats by other respiratory viruses. Moreover, from the results of the clinical trials seem that MVA is particularly attractive for development of vaccines against pathogens for which no, or only insufficiently effective vaccines, are available. (C) 2015 The Authors. Published by Elsevier Ltd.
- Subjects :
- Influenza vaccine
Virus vectored vaccine
Analytic hierarchy process
Vaccinia virus
Vaccine technology platform
Vaccine production platform
Article
Pre-pandemic and Pandemic vaccine
SDG 3 - Good Health and Well-being
Order (exchange)
Immunology and Microbiology(all)
Pandemic
Influenza, Human
Medicine
Humans
SWOT analysis
Pandemics
General Veterinary
General Immunology and Microbiology
business.industry
Modified vaccinia virus Ankara (MVA)
Vaccination
Public Health, Environmental and Occupational Health
Opinion leadership
veterinary(all)
3. Good health
Biotechnology
Infectious Diseases
Risk analysis (engineering)
Influenza Vaccines
Molecular Medicine
Pairwise comparison
business
Influenza virus
Subjects
Details
- Language :
- English
- ISSN :
- 18732518 and 0264410X
- Volume :
- 33
- Issue :
- 35
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....9ce06f056e355d8653cea1fd312bd73a