Highlight report: epoxide hydrolases—protection from reactive compounds and risk of cardiovascular disease

Drug metabolism represents a cutting edge topic in toxicology with a particular focus on toxification versus detoxification of xenobiotics (Oesch et al. 2014; Rodriguez-Mateos et al. 2014; Dohnal et al. 2014), contribution of drug metabolism to oxidative stress (Xiao et al. 2014; Moller et al. 2014; Wu et al. 2014), and regulation of metabolic activity (Juricek et al. 2014; Bitter et al. 2014; Lim et al. 2014; Braeuning 2014). Moreover, recent research focuses on integrating metabolic pathways into mathematical models in order to predict the metabolic capacity of tissues and organs under physiological and disease conditions (Drasdo et al. 2014a, b; Schliess et al. 2014; Hoehme et al. 2010). Finally, compromised xenobiotic metabolism represents one of the major problems in alternative methods and in vitro systems (Godoy et al. 2009, 2013, 2015; Pfeiffer et al. 2015; Heise et al. 2012; Ghallab 2013, 2014a, b; Stewart 2010). The present review of El-Sherbeni and ElKadi represents a must-read for anyone interested in these fields of research.