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Changes of serum chloride and metabolic acid-base state in critical illness
- Source :
- Anaesthesia. 59:1111-1115
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- Alterations of electrolytes and albumin cause metabolic acid-base disorders. It is unclear, however, to what degree these plasma components affect the overall metabolic acid-base state in the course of critical illness. We performed serial analyses of the metabolic acid-base state in 30 critically ill patients over the course of 1 week. We applied a physical-chemical acid-base model and used a linear regression model to determine the influence of sodium, chloride, unmeasured anions and albumin on the net metabolic acid-base state. Progressive hypochloraemia was identified as the main cause of developing metabolic alkalosis. Changes in serum chloride and unmeasured anions were responsible for changes of 41% and 22% in the metabolic acid-base state, respectively. Sodium and albumin played a minor role. In conclusion, chloride is the major determinant of metabolic acid-base state in critical illness.
- Subjects :
- Male
medicine.medical_specialty
Alkalosis
Critical Illness
Sodium
Metabolic alkalosis
Serum albumin
chemistry.chemical_element
Acid-Base Imbalance
Chloride
Chlorides
Internal medicine
medicine
Humans
Serum chloride
Prospective Studies
Intensive care medicine
Serum Albumin
biology
business.industry
Albumin
medicine.disease
Anesthesiology and Pain Medicine
Endocrinology
chemistry
Linear Models
biology.protein
Female
business
medicine.drug
Acid–base imbalance
Subjects
Details
- ISSN :
- 13652044 and 00032409
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Anaesthesia
- Accession number :
- edsair.doi.dedup.....9cc9bc58e7016eacf4fd8195bf4e846d