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Scientific Opinion on Flavouring Group Evaluation 200 (FGE.200): 74 α,β-unsaturated aldehydes and precursors from subgroup 1.1.1 of FGE.19
- Source :
- EFSA Journal, Vol 12, Iss 6 (2014), EFSA Journal, EFSA Journal, European Food Safety Authority, 2014, 12 (6), pp.3709. ⟨10.2903/j.efsa.2014.3709⟩
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 74 flavouring substances from subgroup 1.1.1 of FGE.19 in the Flavouring Group Evaluation 200 (FGE.200). The Flavour Industry has provided additional genotoxicity studies for one representative substance in FGE.200, namely hex-2(trans)-enal [FL-no 05.073], and for other two substances in the same subgroup, namely 2-dodecenal [05.037] and 2-nonenal [05.171]. The Panel has evaluated these data and concluded that the concern still remains with respect to genotoxicity for the substances of this subgroup and their three representative substances. The Panel confirms, the need for an in vivo Comet assay performed in duodenum and liver for hex-2(trans)-enal [FL-no: 05.073]. For the two other representative substances of subgroup 1.1.1 (nona-2(trans),6(cis)-dienal [FL-no: 05.058] and oct-2-enal [FL-no: 05.060]), a combined in vivo Comet assay and micronucleus assay would be required. For the latter, evidence of bone marrow exposure should be provided.
- Subjects :
- Veterinary (miscellaneous)
Group evaluation
Plant Science
TP1-1185
medicine.disease_cause
Microbiology
Straight chain
medicine
Organic chemistry
?
[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering
TX341-641
?-unsaturated aldehydes
subgroup 1.1.1
ComputingMilieux_MISCELLANEOUS
2. Zero hunger
Chemistry
business.industry
Nutrition. Foods and food supply
Chemical technology
FGE.19
safety evaluation
Food safety
straight chain
flavouring substances
FGE.200
Food packaging
Animal Science and Zoology
Parasitology
business
Genotoxicity
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 18314732 and 23149396
- Volume :
- 12
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- EFSA Journal
- Accession number :
- edsair.doi.dedup.....9caa95452274bbff97e672fdcd6f68ba