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Imaging a Fever-Redefining the Role of 2-deoxy-2-[18F]Fluoro-D-Glucose-Positron Emission Tomography/Computed Tomography in Fever of Unknown Origin Investigations
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 72(7)
- Publication Year :
- 2020
-
Abstract
- Growing evidence suggests that 2-deoxy-2-[18F]fluoro-D-glucose (18FDG)–positron emission tomography/computed tomography (PET/CT) is a useful imaging technique for the evaluation of fever of unknown origin (FUO). This imaging technique allows for accurate localization of foci of hypermetabolism based on 18FDG uptake in glycolytically active cells that may represent inflammation, infection, or neoplasia. The presence of abnormal uptake can help direct further investigation that may yield a final diagnosis. A lack of abnormal uptake can be reasonably reassuring that these conditions are not present, thereby avoiding unnecessary additional testing. Insurers have not routinely covered outpatient 18FDG-PET/CT for the indication of FUO in the United States. However, data published since 2007 suggest early use in FUO diagnostic evaluations improves diagnostic efficiency and reduces costs. Clinicians and insurers should consider 18FDG-PET/CT as a useful tool when preliminary studies are unrevealing.
- Subjects :
- Microbiology (medical)
medicine.medical_specialty
Computed tomography
Fever of Unknown Origin
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
medicine
Medical imaging
Humans
030212 general & internal medicine
Fever of unknown origin
Positron Emission Tomography-Computed Tomography
2 deoxy 2 18f fluoro d glucose
Inflammation
medicine.diagnostic_test
business.industry
medicine.disease
Infectious Diseases
Glucose
Positron-Emission Tomography
Hypermetabolism
Radiology
Tomography
Imaging technique
Radiopharmaceuticals
business
Subjects
Details
- ISSN :
- 15376591
- Volume :
- 72
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....9c9cf7c6091ba5daaccbe274f4d263d2