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Calcium and Magnesium Use for Oxaliplatin-Induced Neuropathy: A Case Study to Assess How Quickly Evidence Translates Into Practice
- Source :
- Journal of the National Comprehensive Cancer Network. 13:1097-1101
- Publication Year :
- 2015
- Publisher :
- Harborside Press, LLC, 2015.
-
Abstract
- Substantial research efforts have focused on methods of treating and preventing oxaliplatin-associated neuropathy, the dose-limiting toxicity associated with this drug. Administration of intravenous calcium and magnesium (CaMg) before and after oxaliplatin has been the most studied approach to preventing oxaliplatin-induced neuropathy. Although early reports demonstrated potential benefit, subsequent larger trials failed to confirm the efficacy of CaMg in preventing this adverse effect. This article explores how accumulating evidence for and against the use of CaMg for preventing oxaliplatin-induced neuropathy has impacted clinical practice.
- Subjects :
- Drug
medicine.medical_specialty
Biomedical Research
Organoplatinum Compounds
Minnesota
media_common.quotation_subject
Cetuximab
chemistry.chemical_element
Antineoplastic Agents
Calcium
Translational Research, Biomedical
Humans
Medicine
Magnesium
Practice Patterns, Physicians'
Intensive care medicine
Adverse effect
Retrospective Studies
media_common
Cisplatin
business.industry
Peripheral Nervous System Diseases
digestive system diseases
Oxaliplatin
Surgery
Clinical Practice
Oncology
chemistry
Toxicity
business
Administrative Claims, Healthcare
medicine.drug
Subjects
Details
- ISSN :
- 15401413 and 15401405
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of the National Comprehensive Cancer Network
- Accession number :
- edsair.doi.dedup.....9c9cd9ed3bc58446952246c0748cd480