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Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas—an immunohistochemical study
- Source :
- British Journal of Cancer
- Publication Year :
- 2015
- Publisher :
- Nature Publishing Group, 2015.
-
Abstract
- Background: The prognosis of solid malignancies has been shown to depend on immunological parameters, such as macrophage polarisation (M1/M2). Recently, it was reported that preoperative oral surgery leads to a worsening of oral squamous cell carcinomas (OSCC) prognosis. Diagnostic incision biopsies are oral surgery procedures that might lead to healing-associated M2 macrophage polarisation with a potential negative influence on tumour biology. No studies have compared macrophage polarisation in OSCC biopsies and tumour specimens. Methods: Preoperative diagnostic incision biopsies (n=25) and tumour resection specimens (n=34) of T1/T2 OSCC were processed for immunohistochemistry to detect CD68-, CD11c-, CD163- and MRC1-positive cells. Samples were digitised using whole-slide imaging, and the expression of macrophage markers was quantitatively analysed. Results: Carcinoma tissues obtained during OSCC tumour resections showed a significantly (P
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Time Factors
Biopsy
M1
M2
tumour biopsy
Carcinoma
Medicine
Humans
Lung cancer
Molecular Diagnostics
Mouth neoplasm
medicine.diagnostic_test
business.industry
CD68
Chemotaxis
Macrophages
Cell Polarity
oral cancer
Middle Aged
medicine.disease
M2 Macrophage
peripheral tolerance
Immunohistochemistry
oral squamous cell carcinoma
stomatognathic diseases
Oncology
Carcinoma, Squamous Cell
Disease Progression
Female
Mouth Neoplasms
OSCC
business
macrophage polarisation
CD163
Subjects
Details
- Language :
- English
- ISSN :
- 15321827 and 00070920
- Volume :
- 113
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....9c99ee01daee636123a4e87a298d1043