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SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases
- Source :
- ACS Chemical Biology. 11:583-597
- Publication Year :
- 2015
- Publisher :
- American Chemical Society (ACS), 2015.
-
Abstract
- S -Adenosyl-L-methionine (SAM) is a sulfonium molecule with a structural hybrid of methionine and adenosine. As the second largest cofactor in the human body, its major function is to serve as methyl donor for SAM-dependent methyltransferases (MTases). The resultant transmethylation of biomolecules constitutes a significant biochemical mechanism in epigenetic regulation, cellular signaling, and metabolite degradation. Recently, numerous SAM analogs have been developed as synthetic cofactors to transfer the activated groups on MTase substrates for downstream ligation and identification. Meanwhile, new compounds built upon or derived from the SAM scaffold have been designed and tested as selective inhibitors for important MTase targets. Here, we summarized the recent development and application of SAM analogs as chemical biology tools for MTases.
- Subjects :
- 0301 basic medicine
S-Adenosylmethionine
Cell signaling
Methyltransferase
Stereochemistry
Chemical biology
Biochemistry
Article
Gene Expression Regulation, Enzymologic
Cofactor
Epigenesis, Genetic
03 medical and health sciences
chemistry.chemical_compound
Humans
chemistry.chemical_classification
Methionine
biology
Biomolecule
Methyltransferases
General Medicine
S-Adenosylhomocysteine
030104 developmental biology
chemistry
biology.protein
Molecular Medicine
Transmethylation
Function (biology)
Subjects
Details
- ISSN :
- 15548937 and 15548929
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- ACS Chemical Biology
- Accession number :
- edsair.doi.dedup.....9c948429bf2af0e3ed237d779e2f1f4f