Back to Search
Start Over
A New Triterpenoid from Teucrium viscidum
- Source :
- Molecules; Volume 18; Issue 1; Pages: 1262-1269, Molecules, Vol 18, Iss 1, Pp 1262-1269 (2013), Molecules
- Publication Year :
- 2013
- Publisher :
- MDPI AG, 2013.
-
Abstract
- A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1–4 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).
- Subjects :
- Liquid-Liquid Extraction
Pharmaceutical Science
Dehydrogenase
Article
Teucrium
Analytical Chemistry
lcsh:QD241-441
Structure-Activity Relationship
Teucrium viscidum
chemistry.chemical_compound
Triterpenoid
lcsh:Organic chemistry
Ursolic acid
Microsomes
Drug Discovery
Humans
Enzyme Inhibitors
Physical and Theoretical Chemistry
11β-HSD1
Molecular Structure
Traditional medicine
Chemistry
Organic Chemistry
lignans
triterpenoids
Daucosterol
Triterpenes
HEK293 Cells
Pinoresinol
Chemistry (miscellaneous)
Molecular Medicine
11-beta-Hydroxysteroid Dehydrogenases
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....9c8c5e5e5d0935a9eb5c216204fc5bf7
- Full Text :
- https://doi.org/10.3390/molecules18011262