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Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
- Source :
- Metabolites, Volume 11, Issue 7, Metabolites, Vol 11, Iss 420, p 420 (2021), Metabolites, vol 11, iss 7
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensitivity and secretion. The goal of this study was to conduct such an investigation in a cohort of 353 non-Hispanic White and African American individuals recruited in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). Participants underwent oral glucose tolerance tests from which insulin sensitivity, insulin secretion, insulin clearance, and disposition index were calculated. Regression models examined the individual and joint contributions of these traits to early dysglycemia (prediabetes or newly diagnosed diabetes). In separate models, reduced insulin sensitivity, reduced disposition index, and reduced insulin clearance were associated with dysglycemia. In a joint model, only insulin resistance and reduced insulin secretion were associated with dysglycemia. Models with insulin sensitivity, disposition index, or three insulin traits had the highest discriminative value for dysglycemia (area under the receiver operating characteristics curve of 0.82 to 0.89). These results suggest that in the race groups studied, insulin resistance and compromised insulin secretion are the main independent underlying defects leading to early dysglycemia.
- Subjects :
- 0301 basic medicine
insulin secretion
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Clinical Sciences
030209 endocrinology & metabolism
prediabetes
Type 2 diabetes
Microbiology
Biochemistry
Article
Analytical Chemistry
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Clinical Research
Diabetes mellitus
Internal medicine
medicine
insulin sensitivity
Secretion
Microbiome
Prediabetes
Molecular Biology
Metabolic and endocrine
disposition index
diabetes
business.industry
Insulin
medicine.disease
QR1-502
insulin clearance
030104 developmental biology
Endocrinology
Cohort
Patient Safety
Biochemistry and Cell Biology
business
Subjects
Details
- ISSN :
- 22181989
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Metabolites
- Accession number :
- edsair.doi.dedup.....9c7c709c251a9c7f76fc9afb8ff6579e
- Full Text :
- https://doi.org/10.3390/metabo11070420