Back to Search Start Over

Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)

Authors :
Alain G. Bertoni
Yii-Der Ida Chen
Mark O. Goodarzi
Gautam Ramesh
Elizabeth T. Jensen
Stephen S. Rich
Alexis C. Wood
Jerome I. Rotter
Source :
Metabolites, Volume 11, Issue 7, Metabolites, Vol 11, Iss 420, p 420 (2021), Metabolites, vol 11, iss 7
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensitivity and secretion. The goal of this study was to conduct such an investigation in a cohort of 353 non-Hispanic White and African American individuals recruited in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). Participants underwent oral glucose tolerance tests from which insulin sensitivity, insulin secretion, insulin clearance, and disposition index were calculated. Regression models examined the individual and joint contributions of these traits to early dysglycemia (prediabetes or newly diagnosed diabetes). In separate models, reduced insulin sensitivity, reduced disposition index, and reduced insulin clearance were associated with dysglycemia. In a joint model, only insulin resistance and reduced insulin secretion were associated with dysglycemia. Models with insulin sensitivity, disposition index, or three insulin traits had the highest discriminative value for dysglycemia (area under the receiver operating characteristics curve of 0.82 to 0.89). These results suggest that in the race groups studied, insulin resistance and compromised insulin secretion are the main independent underlying defects leading to early dysglycemia.

Details

ISSN :
22181989
Volume :
11
Database :
OpenAIRE
Journal :
Metabolites
Accession number :
edsair.doi.dedup.....9c7c709c251a9c7f76fc9afb8ff6579e
Full Text :
https://doi.org/10.3390/metabo11070420