ДИНАМІКА ПРОЦЕСІВ ЛІПІДНОЇ ПЕРОКСИДАЦІЇ ТА АНТИОКСИДАНТНОГО ЗАХИСТУ ЗА ТЯЖКОЇ ПОЄДНАНОЇ ТРАВМИ ОРГАНІВ ЧЕРЕВНОЇ ПОРОЖНИНИ В ЕКСПЕРИМЕНТІ

Introduction. Traumaticity constitutes one of actual problems of urgent surgery. The lipids peroxidal oxidation (LPO) activation and the antioxidant defense (AOD) system depletion are important aspects of the hepatic dysfunction pathogenesis as well as hepatic insufficiency in the trauma environment. Маterials and methods. The closed abdominal organs (AO) trauma in combination with bilateral femoral fractures was simulated in experiment on 74 white rats. The hepatic content of the LPO products and activity of the AOD enzymatic unit were investigated. Results. Activation of the lipids peroxidation processes was observed in the laboratory animals liver in the AO combined trauma. Discussion. The results obtained witness the necessity for the LPO processes correction in complex of the AO combined trauma in early period of traumatic disease. Conclusion. Dynamics of the superoxiddysmutase and catalase activity, as well as of the antioxidant–prooxidant index, witness a significant compensatory reaction of the hepatic АОD system present in environment of the combined AO trauma.