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METABOLISM OF D-CEPHALOGLYCIN-14C AND L-CEPHALOGLYCIN-14C IN THE RAT
- Source :
- The Journal of Antibiotics. 22:27-33
- Publication Year :
- 1969
- Publisher :
- Japan Antibiotics Research Association, 1969.
-
Abstract
- The fate of the orally effective antibiotic D-cephaloglycin and its much less active L-enantiomer has been studied in the rat. D-Cephaloglycin-14C is metabolized by two pathways, (1) hydrolysis of the amide linkage to form D-2-phenylglycine-14C and (2) deacetylation to form deacetyl-D-cephaloglycin-14C. D-Cephaloglycin is absorbed from the gastro-intestinal tract at least in part as the intact antibiotic, L-Cephaloglycin-14C is rapidly metabolized to L-2-phenylglycine-14C and its metabolites. In contrast to the results with D-cephaloglycin-14C, no intact L-cephaloglycin-14C or deacetyl-L-cephaloglycin was excreted in the urine of rats.
- Subjects :
- Formates
Chromatography, Paper
medicine.drug_class
Antibiotics
Urine
Biology
Pharmacology
Feces
Hydrolysis
chemistry.chemical_compound
Amide
Drug Discovery
medicine
Animals
Bile
Cephaloglycin
Carbon Isotopes
Metabolism
Anti-Bacterial Agents
Rats
Intestinal Absorption
chemistry
Biochemistry
Acetylation
Mandelic Acids
Injections, Intraperitoneal
Subjects
Details
- ISSN :
- 18811469 and 00218820
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- The Journal of Antibiotics
- Accession number :
- edsair.doi.dedup.....9c66a03371448fdcad4799a99da50428