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Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study
- Source :
- Brain Sciences, Brain Sciences, Vol 10, Iss 408, p 408 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.
- Subjects :
- Oncology
medicine.medical_specialty
Lithium (medication)
CD34
lcsh:RC321-571
Nicotine
Pathogenesis
03 medical and health sciences
0302 clinical medicine
stem cells
Internal medicine
medicine
VSEL
Bipolar disorder
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
bipolar disorder
business.industry
General Neuroscience
Communication
Case-control study
medicine.disease
030227 psychiatry
Stem cell
business
Body mass index
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20763425
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Brain Sciences
- Accession number :
- edsair.doi.dedup.....9c5ef9d73ab909d679e90f98f4d369dc