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Central nervous system development-related microRNAs levels increase in the serum of gestational diabetic women during the first trimester of pregnancy
- Source :
- Neuroscience Research. 130:8-22
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- MicroRNAs are heterochronic molecules important during brain development, which could be altered by gestational diabetes mellitus (GDM). To explore these molecules in maternal serum, we performed an RT-qPCR analysis. Our results revealed the heterochronic character of some neural development-related microRNA in serum samples of pregnant women. In relation to the first trimester, higher levels of miR-183-5p, -200b-3p, and -125-5p in the second trimester, and higher levels of miR-137 in the third trimester, were found. Furthermore, an insult such as GDM led to higher levels of miR-183-5p, -200b-3p, -125-5p, and -1290 relative to the control in the first trimester, which might be related to changes in neurogenesis and cell proliferation. An in silico analysis suggested that increased microRNAs in the second trimester in the control contributed to cell proliferation and neuron differentiation and that the rise in miR-137 in the third trimester led to neuron maturation. In the diabetic, higher levels of the microRNAs in the first trimester suggested alterations in cell proliferation and neuron differentiation. In conclusion, we showed that fetal-related microRNAs can be detected in the serum of pregnant woman and exhibit temporary regulation during pregnancy and that microRNAs involved in cell proliferation and neuron differentiation are upregulated under GDM.
- Subjects :
- Adult
Central Nervous System
0301 basic medicine
medicine.medical_specialty
Adolescent
Central nervous system
Biology
Real-Time Polymerase Chain Reaction
Young Adult
03 medical and health sciences
Pregnancy
Internal medicine
microRNA
medicine
Humans
Computer Simulation
General Neuroscience
Neurogenesis
General Medicine
medicine.disease
Gestational diabetes
Diabetes, Gestational
MicroRNAs
Pregnancy Trimester, First
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Neuron maturation
Neuron differentiation
Gestation
Female
Signal Transduction
Subjects
Details
- ISSN :
- 01680102
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Neuroscience Research
- Accession number :
- edsair.doi.dedup.....9c5b930715ef4f662c6efeb69d6cc6ec