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Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects
- Source :
- Ray, J C, Kapoor, M, Stark, R J, Wang, S J, Bendtsen, L, Matharu, M & Hutton, E J 2021, ' Calcitonin gene related peptide in migraine : Current therapeutics, future implications and potential off-target effects ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 92, no. 12, pp. 1325-1334 . https://doi.org/10.1136/jnnp-2020-324674
- Publication Year :
- 2020
-
Abstract
- Migraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes of therapeutics have been specifically developed to combat migraine. After 30 years of translational research, calcitonin gene-related peptide (CGRP) inhibitors have emerged as a promising new tool in the prevention of migraine. Like all new therapeutics; however, we have limited real-world experience and CGRP has several known systemic actions that warrant consideration. This article provides a narrative review of the evidence for CGRP antagonists and summarises the known and potential side effects that should be considered.
- Subjects :
- 0301 basic medicine
Drug trial
Migraine Disorders
Translational research
Calcitonin gene-related peptide
Bioinformatics
03 medical and health sciences
0302 clinical medicine
Calcitonin Gene-Related Peptide Receptor Antagonists
medicine
Humans
migraine
business.industry
drug trials
medicine.disease
Psychiatry and Mental health
030104 developmental biology
Treatment Outcome
Migraine
Calcitonin
Surgery
Narrative review
Neurology (clinical)
business
headache
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1468330X
- Volume :
- 92
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Accession number :
- edsair.doi.dedup.....9c5ace4f44ef43a5092e19981e467812