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Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma

Authors :
Bing-Shen Huang
Joseph Tung-Chieh Chang
Kai-Ping Chang
Ping-Ching Pai
Tsung-Min Hung
Chien-Yu Lin
Kang-Hsing Fan
Ngan-Ming Tsang
Wing-Keen Yap
Yao-Yu Wu
Yung-Chih Chou
Chun-Ta Liao
Yin-Yin Chiang
Source :
Radiation Oncology, Vol 15, Iss 1, Pp 1-9 (2020), Radiation Oncology (London, England)
Publication Year :
2020
Publisher :
BMC, 2020.

Abstract

BackgroundWe sought to investigate the prognostic impact of missed RT sessions in patients who had undergone surgery for oral cavity squamous cell carcinoma (OCSCC).MethodsThe study sample consisted of 905 patients with surgically treated OCSCC who fulfilled criteria of RT course ≤8 weeks. The study participants were divided into three groups based on the characteristics of missed RT, as follows: 1) early missed RT, 2) late missed RT, and 3) RT as scheduled.ResultsThe 5-year overall survival (OS) rates in the early missed RT, late missed RT, and RT as scheduled groups were 53.0, 58.1, and 64.5%, respectively (p = 0.046). In multivariate analysis, early missed RT was independently associated with both OS (hazard ratio (HR) = 1.486; 95% confidence interval (CI): 1.122–1.966;p = 0.006) and the occurrence of distant metastasis (HR = 1.644; 95% CI: 1.047–2.583;p = 0.031).ConclusionEarly missed RT was independently associated with a higher occurrence of distant metastasis and less favorable OS in patients who had undergone surgery for OCSCC.

Details

Language :
English
Volume :
15
Issue :
1
Database :
OpenAIRE
Journal :
Radiation Oncology
Accession number :
edsair.doi.dedup.....9c466ff0e01d43d433da2294a3af113d