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Inactivation of C3H10T1/2 cells by low energy protons and deuterons
- Source :
- International journal of radiation biology. 73(3)
- Publication Year :
- 1998
-
Abstract
- Purpose To determine the RBE-LET relationship for C3H10T1/2 cell inactivation by protons in the LET range 11-33 keV/microm and to compare inactivation frequencies induced in C3H10T1/2 cells by protons and deuterons at two matching LET values in the range 11-20 keV/microm. Materials and methods C3H10T1/2 cells were irradiated with protons and deuterons at the radiobiological facility set up at the 7MV Van de Graaff accelerator at the LNL, Legnaro, Padova. Gamma rays from 60Co were used as reference radiation. Results Proton RBE values (alpha/alphagamma) for inactivation of C3H10T1/2 cells are constant around a value of 2 between 11 and 20 keV/microm and then rise sharply to reach a value of 4.2+/-1.0 at 33 keV/microm. Deuteron RBE values are 1.7+/-0.4 and 2.2+/-0.6 at LET values of 13 and 18 keV/microm respectively. Conclusions Proton RBE values with C3H10T1/2 cells are significantly larger than unity at LET values as low as 11 keV/microm. No difference in effectiveness for inactivation of C3H10T1/2 has been found between protons and deuterons at two LET values in the range 10-20 keV/microm.
- Subjects :
- Proton
Cell Survival
Linear energy transfer
law.invention
Nuclear physics
Mice
law
Van de Graaff generator
Relative biological effectiveness
Animals
Radiology, Nuclear Medicine and imaging
Linear Energy Transfer
Irradiation
Cells, Cultured
Range (particle radiation)
Mice, Inbred C3H
Radiological and Ultrasound Technology
Chemistry
Gamma ray
Dose-Response Relationship, Radiation
equipment and supplies
Deuterium
Gamma Rays
embryonic structures
Particle Accelerators
Protons
Relative Biological Effectiveness
Subjects
Details
- ISSN :
- 09553002
- Volume :
- 73
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International journal of radiation biology
- Accession number :
- edsair.doi.dedup.....9c4177dde962842852f9bba3eceab984