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The natural substrate for nitric oxide synthase activity
- Source :
- Cell biochemistry and function. 19(4)
- Publication Year :
- 2001
-
Abstract
- There has been little evidence to indicate that arginine is the natural substrate for generating nitric oxide synthase (NOS) activity. It is now shown that carnosine, which is widely distributed in tissues, is likely to be the true substrate. In tissue sections it gives a stronger NOS reaction than does arginine.
- Subjects :
- Liver chemistry
Time Factors
Arginine
Clinical Biochemistry
Carnosine
NADP metabolism
Biochemistry
Substrate Specificity
chemistry.chemical_compound
Arginine metabolism
Animals
Rats, Wistar
biology
Substrate (chemistry)
Cell Biology
General Medicine
Hydrogen-Ion Concentration
Rats
Nitric oxide synthase
Tissue sections
chemistry
Liver
biology.protein
Female
Nitric Oxide Synthase
NADP
Subjects
Details
- ISSN :
- 02636484
- Volume :
- 19
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cell biochemistry and function
- Accession number :
- edsair.doi.dedup.....9c3a49da30f7626897cd74cb760e0ff4