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Recommendations concerning the new U.S. National Institutes of Health initiative to balance the sex of cells and animals in preclinical research
- Source :
- The FASEB Journal. 29:1646-1652
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- The U.S. National Institutes of Health (NIH) announced last May that steps will be taken to address the over-reliance on male cells and animals in preclinical research. To further address this announcement, in September 2014, scientists with varying perspectives came together at Georgetown University to discuss the following questions. (1) What metrics should the NIH use to assess tangible progress on policy changes designed to address the over-reliance on male cells and animals in preclinical research? (2) How effective can education be in reducing the over-reliance on male cells and animals in preclinical research and what educational initiatives sponsored by the NIH would most likely effect change? (3) What criteria should the NIH use to determine rigorously defined exceptions to the future proposal requirement of a balance of male and female cells and animals in preclinical studies? (4) What additional strategies in addition to proposal requirements should NIH use to reduce the overreliance of male cells and animals in preclinical research? The resulting consensus presented herein includes input from researchers not only from diverse disciplines of basic and translational science including biology, cell and molecular biology, biochemistry, physiology, pharmacology, neuroscience, cardiology, endocrinology, nephrology, psychiatry, and obstetrics and gynecology, but also from recognized experts in publishing, industry, advocacy, science policy, clinical medicine, and population health. We offer our recommendations to aid the NIH as it selects, implements, monitors, and optimizes strategies to correct the over-reliance on male cells and animals in preclinical research.—Sandberg, K., Umans, J. G., Georgetown Consensus Conference Work Group. Recommendations concerning the new U.S. National Institutes of Health initiative to balance the sex of cells and animals in preclinical research.
- Subjects :
- Animal Experimentation
Male
Gerontology
Research design
medicine.medical_specialty
Research Subjects
MEDLINE
Alternative medicine
Guidelines as Topic
Population health
Biochemistry
Translational Research, Biomedical
Preclinical research
Sex Factors
Genetics
Animals
Humans
Medicine
Animal testing
Molecular Biology
Sex Characteristics
Medical education
business.industry
United States
Disease Models, Animal
National Institutes of Health (U.S.)
Research Design
Female
Science policy
Life Sciences Forum
Translational science
business
Biotechnology
Subjects
Details
- ISSN :
- 15306860 and 08926638
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- The FASEB Journal
- Accession number :
- edsair.doi.dedup.....9c2baeb172381e9bb46ca53b5de86be4