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Preclinical and clinical studies to evaluate cutaneous biodistribution, safety and efficacy of UV filters encapsulated in mesoporous silica SBA-15
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Innovative technologies have been designed to improve efficacy and safety of chemical UV filters. Encapsulation can enhance efficacy and reduce transdermal permeation and systemic exposure. The aims of this work were (i) to determine the cutaneous biodistribution of avobenzone (AVO), oxybenzone (OXY), and octyl methoxycinnamate (OMC) incorporated in mesoporous silica SBA-15 and (ii) to perform preclinical (in vitro) and (iii) clinical safety studies to demonstrate their innocuity and to evaluate sun protection factor (SPF) in humans. Skin penetration studies showed that deposition of OXY and AVO in porcine and human skin after application of stick formulation with incorporated filters (stick incorporated filters) was significantly lower than from a marketed (non-encapsulated) stick. Cutaneous deposition and transdermal permeation of OXY in and across human skin were 3.8-and 13.4- fold lower, respectively, after application of stick entrapped filters. Biodistribution results showed that encapsulation in SBA-15 decreased AVO and OXY penetration reaching porcine and human dermis. Greater deposition (and permeation) of OXY in porcine skin than in human skin, pointed to the role of follicular transport. Stick incorporated filters had good biocompatibility in vivo and safety profiles, even under sun-exposed conditions. Entrapment of UV filters improved the SPF by 26% and produced the same SPF profile as a marketed stick. Overall, the results showed that SBA-15 enabled safety and efficacy of UV filters to be increased.
- Subjects :
- Biodistribution
Biocompatibility
Swine
Drug Compounding
Skin Absorption
Drug Evaluation, Preclinical
Pharmaceutical Science
Human skin
Administration, Cutaneous
Benzophenones
chemistry.chemical_compound
Animals
Humans
Tissue Distribution
Propiophenones
TECNOLOGIAS DA SAÚDE
Chemistry
Micropore Filters
Octyl methoxycinnamate
General Medicine
Mesoporous silica
Permeation
Silicon Dioxide
Cinnamates
Avobenzone
Oxybenzone
Sun Protection Factor
Sunscreening Agents
Biotechnology
Biomedical engineering
Subjects
Details
- ISSN :
- 09396411
- Volume :
- 169
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmaceutics and Biopharmaceutics
- Accession number :
- edsair.doi.dedup.....9c26c9beb456b3fa15119378c8ba103b