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Variation and transmission of the human gut microbiota across multiple familial generations
- Source :
- Nature Microbiology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Although the composition and functional potential of the human gut microbiota evolve over the lifespan, kinship has been identified as a key covariate of microbial community diversification. However, to date, sharing of microbiota features within families has mostly been assessed between parents and their direct offspring. Here we investigate the potential transmission and persistence of familial microbiome patterns and microbial genotypes in a family cohort (n = 102) spanning 3 to 5 generations over the same female bloodline. We observe microbiome community composition associated with kinship, with seven low abundant genera displaying familial distribution patterns. While kinship and current cohabitation emerge as closely entangled variables, our explorative analyses of microbial genotype distribution and transmission estimates point at the latter as a key covariate of strain dissemination. Highest potential transmission rates are estimated between sisters and mother–daughter pairs, decreasing with increasing daughter’s age and being higher among cohabiting pairs than those living apart. Although rare, we detect potential transmission events spanning three and four generations, primarily involving species of the genera Alistipes and Bacteroides. Overall, while our analyses confirm the existence of family-bound microbiome community profiles, transmission or co-acquisition of bacterial strains appears to be strongly linked to cohabitation.<br />Quantitative metagenomic analyses of gut microbiomes reveals kinship, together with current cohabitation, as drivers of microbial community transmission and persistence between family members over three to five generations.
- Subjects :
- Adult
Microbiology (medical)
16S
Adolescent
Immunology
DIVERSITY
CHILDREN
Bacterial Physiological Phenomena
Applied Microbiology and Biotechnology
Microbiology
Article
Cohort Studies
LIKELIHOOD
Feces
Young Adult
RICHNESS
RNA, Ribosomal, 16S
REGRESSION
80 and over
Genetics
Humans
Family
R PACKAGE
Preschool
Child
Aged
LEVEL ANALYSIS
Ribosomal
Aged, 80 and over
RISK
Science & Technology
Bacteria
Cell Biology
Child, Preschool
Female
Gastrointestinal Microbiome
Metagenomics
Middle Aged
Metagenome
CATALOG
BODY-MASS INDEX
RNA
Microbiome
Life Sciences & Biomedicine
Subjects
Details
- ISSN :
- 20585276
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Nature Microbiology
- Accession number :
- edsair.doi.dedup.....9c102a2f6282875acbe86d0f4b1874b7