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ANXIOUS BEHAVIOR INDUCES ELEVATED HIPPOCAMPAL Cb2 RECEPTOR GENE EXPRESSION
- Publication Year :
- 2017
-
Abstract
- Anxiety is differentially expressed across a continuum of stressful/fearful intensity, influenced by endocannabinoid systems and receptors. The hippocampus plays important roles in the regulation of affective behavior, emotion, and anxiety, as well as memory. Location of Cb1/Cb2 receptor action could be important in determining emotional valence, because while the dorsal hippocampus is involved in spatial memory and cognition, the ventral hippocampus has projections to the PFC, BNST, amygdala, and HPA axis, and is important for emotional responses to stress. During repeated social defeat in a Stress-Alternatives Model arena (SAM; an oval open field with escape portals only large enough for smaller mice), smaller C57BL6/N mice are subject to fear conditioning (tone=CS), and attacked by novel larger aggressive CD1 mice (US) over four daily (5min) trials. Each SAM trial presents an opportunity for escape or submission, with stable behavioral responses established by the second day of interaction. Additional groups had access to a running wheel. Social aggression plus fear conditioning stimulates enhanced Cb2 receptor gene expression in the dorsal CA1, dorsal and ventral dentate gyrus subregions in animals displaying a submissive behavioral phenotype. Escape behavior is associated with reduced Cb2 expression in the dorsal CA1 region, with freezing and escape latency correlated with mRNA levels. Escaping and submitting animals with access to running wheels had increased Cb2 mRNA in dorsal DG/CA1. These results suggest that the Cb2 receptor system is rapidly induced during anxiogenic social interactions plus fear conditioning or exercise; with responses potentially adaptive for coping mechanisms.
- Subjects :
- 0301 basic medicine
Male
Hippocampus
Hippocampal formation
Amygdala
Open field
Article
Social defeat
Receptor, Cannabinoid, CB2
03 medical and health sciences
Mice
0302 clinical medicine
Receptor, Cannabinoid, CB1
Escape Reaction
Physical Conditioning, Animal
Conditioning, Psychological
Receptors, Transferrin
medicine
Animals
Interpersonal Relations
Fear conditioning
RNA, Messenger
Maze Learning
General Neuroscience
Dentate gyrus
Fear
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Anxiogenic
nervous system
Acoustic Stimulation
Gene Expression Regulation
lipids (amino acids, peptides, and proteins)
Psychology
Neuroscience
030217 neurology & neurosurgery
Stress, Psychological
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9c0b983136bde7eaf73300464f6c6072