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Circulating Levels of a Soluble Form of Receptor for Advanced Glycation End Products and High-Mobility Group Box Chromosomal Protein 1 in Patients With Acute Pancreatitis
- Source :
- Pancreas. 38:e215-e220
- Publication Year :
- 2009
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2009.
-
Abstract
- OBJECTIVES: To study in patients with acute pancreatitis (AP) the plasma soluble form of the receptor for advanced glycation end products (sRAGE) and high-mobility group box chromosomal protein 1 (HMGB1) levels, followed-up for 12 days after hospitalization, in relation to the occurrence of organ failure and mortality. METHODS: Thirty-eight patients with severe AP and organ failure (grade 2). A control group (127 patients) consisted of 38 patients with severe AP without organ failure (grade 1) and 89 patients with mild AP (grade 0). Plasma samples for determination of HMGB1 and sRAGE levels were collected on admission and on days 1 and 2, days 3 and 4, and days 7 and 12 after admission. RESULTS: The median of the highest sRAGE levels was higher in grade 2 patients (472 pg/mL; interquartile range [IQR], 259-912) than in grade 0 plus grade 1 patients (349 pg/mL; IQR, 209-544; P = 0.024). Among the patients with detectable HMGB1, the median of the highest HMGB1 levels was 117 ng/mL (IQR, 56-212; n = 24) in grade 2 patients and 87 ng/mL (IQR, 54-161; n = 62) in grade 0 plus grade 1 patients (P = 0.310). CONCLUSIONS: We demonstrate that sRAGE level, but not HMGB1 level, is significantly higher in AP patients who develop organ failure than in AP patients without organ failure who recover.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Endocrinology, Diabetes and Metabolism
Receptor for Advanced Glycation End Products
Severity of Illness Index
Gastroenterology
Young Adult
03 medical and health sciences
0302 clinical medicine
Endocrinology
Interquartile range
Glycation
Internal medicine
Severity of illness
Internal Medicine
medicine
Humans
Renal Insufficiency
HMGB1 Protein
Receptors, Immunologic
Young adult
Receptor
Aged
030304 developmental biology
Aged, 80 and over
0303 health sciences
Hepatology
business.industry
Middle Aged
Prognosis
Respiration Disorders
medicine.disease
3. Good health
Surgery
High-mobility group
Pancreatitis
030220 oncology & carcinogenesis
Acute Disease
Acute pancreatitis
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 08853177
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....9bf5b09459e60a40aaac7da063678e77