Phase II trial with sequential clofarabine and cyclophosphamide for refractory and relapsed philadelphia-negative adult acute lymphoblastic leukemia. Results of the GIMEMA LAL 1610 protocol

Authors :: Anna Maria Scattolin
Martina Canichella
Paola Fazi
Ernesta Audisio
Antonella Vitale
Sabina Chiaretti
Nicola Cascavilla
Robin Foà
Elisa Cerqui
Mariangela Iodice
Irene Della Starza
Stefania Paolini
Francesca Paoloni
Francesco Fabbiano
Marco Vignetti
Paola Perfetti
Mario Delia
Renato Bassan
Monica Fumagalli
Caterina Micò
Source :: Leukemia & Lymphoma. 60:3482-3492
Publication Year :: 2019
Publisher :: Informa UK Limited, 2019.
Abstract: Clofarabine (CLO) and cyclophosphamide (CY) combinations were tested in late stage refractory/relapsed (R/R) acute lymphoblastic leukemia (ALL) with disappointing results and high-grade toxicity. We designed a sequential 5-day combination of CLO 40 mg/m

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