Back to Search
Start Over
Preoperative oral rehydration therapy with 2.5 % carbohydrate beverage alleviates insulin action in volunteers
- Source :
- Journal of Artificial Organs. 16:483-488
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Preoperative carbohydrate loading enhances insulin action by approximately 50 %. In some Japanese hospitals, preoperative oral rehydration therapy is performed for preventing dehydration during surgery. We hypothesized that preoperative oral rehydration therapy with a 2.5 % carbohydrate beverage that is widely used in Japan can enhance insulin action. Therefore, we investigated the effect of this 2.5 % carbohydrate beverage on insulin action in volunteers. Six healthy volunteers participated in this crossover randomized study. The participants were segregated into 2 groups: an oral rehydration therapy with 2.5 % carbohydrate beverage group (group A) and a control group (group B). Subjects in group B were allowed to drink only water from 9 pm the day before the test; conversely, group A fasted from 9 pm onward and drank 500 ml of the beverage containing 2.5 % carbohydrate (OS-1; Otsuka Pharmaceutical Factory, Tokushima, Japan) between 9 and 12 pm and again at 6.30 am. At 8.30 am, a hyperinsulinemic normoglycemic clamp was initiated using an artificial pancreas STG-22 (Nikkiso, Tokyo, Japan). Insulin action was evaluated in both groups using the glucose infusion rate. Blood glucose levels at the initiation of the clamp procedure were similar. However, the glucose infusion rate for group A was significantly higher than that of group B (8.6 ± 1.5 vs. 6.8 ± 2.0 mg/kg/min, p = 0.009). In conclusion, the hyperinsulinemic normoglycemic clamp using an artificial pancreas showed that the administration of a 2.5 % carbohydrate oral rehydration solution for preoperative oral rehydration therapy improves insulin action in volunteers.
- Subjects :
- Adult
Male
Pancreas, Artificial
medicine.medical_specialty
medicine.medical_treatment
Biomedical Engineering
Medicine (miscellaneous)
Gastroenterology
Preoperative care
Artificial pancreas
Group B
Biomaterials
Insulin resistance
Internal medicine
Preoperative Care
Humans
Medicine
Carbohydrate loading
Oral rehydration therapy
business.industry
Insulin
Carbohydrate
medicine.disease
Healthy Volunteers
Endocrinology
Fluid Therapy
Female
Insulin Resistance
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 16190904 and 14347229
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Artificial Organs
- Accession number :
- edsair.doi.dedup.....9bf30a1a755e8a74b96d19334143c2b9