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Green cardamom plus low-calorie diet can decrease the expression of inflammatory genes among obese women with polycystic ovary syndrome: a double-blind randomized clinical trial
- Source :
- Eating and Weight Disorders
- Publication Year :
- 2021
-
Abstract
- Purpose Polycystic ovary syndrome (PCOS) is an endocrine disorder and a common cause of infertility among women that is associated with low-grade inflammation. Therefore, the current randomized, double-blind, placebo-controlled clinical trial was conducted to assess the effects of green cardamom supplementation on the serum level of inflammatory markers and their gene expression among obese women with PCOS. Methods We included 194 obese women with PCOS and administered low-calorie diet to all of them. These subjects were randomly divided into two groups including the intervention group with 3 g/day green cardamom (n = 99) and the placebo group (n = 95). Anthropometric indices, androgen hormones, and inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and C-reactive protein (CRP)] were assessed before and after the 4-month intervention. TNF-α, IL-6, and CRP gene expression levels were measured using reverse transcription-polymerase chain reaction (RT-PCR) method. Results Anthropometric indices were improved in both studied groups (P
- Subjects :
- Infertility
medicine.medical_specialty
medicine.drug_class
RT-PCR
Dehydroepiandrosterone
Interleukin 6
Iran
Gastroenterology
law.invention
C-reactive protein
Randomized controlled trial
Double-Blind Method
law
Internal medicine
medicine
Humans
Obesity
Polycystic ovary syndrome
Caloric Restriction
Elettaria
biology
business.industry
medicine.disease
Androgen
Polycystic ovary
Tumor necrosis factor-α
Clinical trial
Psychiatry and Mental health
Clinical Psychology
Dietary Supplements
biology.protein
Female
Original Article
Gene expression
business
Hormone
Subjects
Details
- ISSN :
- 15901262
- Volume :
- 27
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Eating and weight disorders : EWD
- Accession number :
- edsair.doi.dedup.....9bec4502f3ade421bdc31787e44063ef