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Equivalence of metabolite fragments and flow analysis of isotopomer distributions for flux estimation
- Source :
- Transactions on Computational Systems Biology VI ISBN: 9783540457794, Trans. Computational Systems Biology, University of Helsinki
- Publication Year :
- 2006
- Publisher :
- Springer, 2006.
-
Abstract
- The most accurate estimates of the activity of metabolic pathways are obtained by conducting isotopomer tracer experiments. The success of this method, however, is intimately dependent on the quality and amount of data on isotopomer distributions of intermediate metabolites. In this paper we present a novel method for discovering sets of metabolite fragments that always have identical isotopomer distributions, regardless of the velocities of the reactions in the metabolic network. We outline several applications of this equivalence concept, including improved propagation of measurements, experiment planning and consistency checking of metabolic network. Our computational experiments in measurement propagation indicate that the improvement via the use of this technique may be substantial.
- Subjects :
- 0106 biological sciences
0303 health sciences
Metabolite
Metabolic network
01 natural sciences
Isotopomers
03 medical and health sciences
chemistry.chemical_compound
chemistry
010608 biotechnology
Isotopomer distribution
TRACER
Statistics
Biological system
Equivalence (measure theory)
030304 developmental biology
Mathematics
Subjects
Details
- Language :
- English
- ISBN :
- 978-3-540-45779-4
- ISBNs :
- 9783540457794
- Database :
- OpenAIRE
- Journal :
- Transactions on Computational Systems Biology VI ISBN: 9783540457794, Trans. Computational Systems Biology, University of Helsinki
- Accession number :
- edsair.doi.dedup.....9be843f2b4e0285c489366cb6f235fde