Back to Search
Start Over
Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb
- Source :
- Cell. (6):1056-1067
- Publisher :
- Elsevier Inc.
-
Abstract
- SummaryIn the mouse olfactory system, the anatomical locations of olfactory sensory neurons (OSNs) roughly correlate with their axonal projection sites along the dorsal-ventral (D-V) axis of the olfactory bulb (OB). Here we report that an axon guidance receptor, Neuropilin-2 (Nrp2), and its repulsive ligand, Semaphorin-3F (Sema3F), are expressed by OSNs in a complementary manner that is important for establishing olfactory map topography. Sema3F is secreted by early-arriving axons of OSNs and is deposited at the anterodorsal OB to repel Nrp2-positive axons that arrive later. Sequential arrival of OSN axons as well as the graded and complementary expression of Nrp2 and Sema3F by OSNs help to form the topographic order along the D-V axis.
- Subjects :
- Olfactory system
Gene Expression
Sensory system
Nerve Tissue Proteins
Receptors, Cell Surface
Biology
General Biochemistry, Genetics and Molecular Biology
MOLNEURO
Mice
X Chromosome Inactivation
Animals
Secretion
Mice, Knockout
Biochemistry, Genetics and Molecular Biology(all)
Membrane Proteins
Anatomy
respiratory system
Olfactory neuron
Olfactory Bulb
Axons
Olfactory bulb
Neuropilin-2
nervous system
Axon guidance
sense organs
SYSNEURO
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....9bdb4ad342050e7f02311d736586fcae
- Full Text :
- https://doi.org/10.1016/j.cell.2010.04.041