Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis

Objective: To estimate association between androgen receptor (AR) gene polymorphisms and testicular germ cell tumor (TGCT) susceptibility. Materials and Methods: Systematic search of studies on the association between AR gene polymorphisms and TGCT susceptibility was conducted. Odds ratios and 95% confidence intervals were used to pool effect size. Results: For CAG repeat, no evidence was found for association between (>25 vs. ≤25), (>25 vs. 21–25), (23 vs. ≤23), (24 vs. ≤24), (>24 vs. 21–24), ( A, rs1204038 G > A and rs2361634 A > G, no statistical change was found without sensitivity analysis. Conclusions: GGN repeat number 23, CAG repeat number, SNP rs6152, rs1204038, and rs2361634.