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Wide-field contact specular microscopy analysis of corneal endothelium post trabeculectomy
- Source :
- Graefe's Archive for Clinical and Experimental Ophthalmology. 256:751-757
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- This study investigates the possible role of the filtration bleb in the continuous decrease in corneal endothelial cell (CEC) density observed following trabeculectomy. This study involved 51 eyes of 37 glaucoma patients who underwent trabeculectomy. The CEC density was determined by contact specular microscopy in three areas: (1) the cornea center, (2) near the trabeculectomy filtration bleb, and (3) the opposite side of the bleb. The eyes were grouped according to post-surgical follow-up years: 0–1 (Group 1), 1–2 (Group 2), 2–3 (Group 3), 3–4, (Group 4), and 4+ years (Group 5). The mean CEC densities at the opposite side of the bleb, in the cornea center, and near the bleb were 2210 ± 487, 1930 ± 528, and 1519 ± 507 cells/mm2, respectively, in all eyes. The CEC density was significantly lower near the bleb than at the other two sites. The coefficient of variation was significantly higher near the bleb than at the other two sites. The CEC densities at the cornea center and at the opposite side of the bleb showed no significant differences. However, the CEC densities near the bleb showed time-dependent decreases to 1790, 1601, 1407, 1339, and 1224 cells/mm2 for Groups 1, 2, 3, 4, and 5, respectively. CEC density following trabeculectomy decreased near the bleb, but not at the cornea center, suggesting that the involvement of the filtration bleb in CEC density loss should be further examined to elucidate the pathology of CEC loss following trabeculectomy.
- Subjects :
- Male
Corneal endothelium
medicine.medical_specialty
genetic structures
medicine.medical_treatment
Glaucoma
Cell Count
Trabeculectomy
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Ophthalmology
Cornea
medicine
Humans
Postoperative Period
Bleb (cell biology)
Intraocular Pressure
Aged
Retrospective Studies
Aged, 80 and over
Microscopy
Chemistry
Endothelium, Corneal
Middle Aged
medicine.disease
Wide field
eye diseases
Sensory Systems
medicine.anatomical_structure
SPECULAR MICROSCOPY
cardiovascular system
030221 ophthalmology & optometry
Female
Corneal endothelial cell
sense organs
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 1435702X and 0721832X
- Volume :
- 256
- Database :
- OpenAIRE
- Journal :
- Graefe's Archive for Clinical and Experimental Ophthalmology
- Accession number :
- edsair.doi.dedup.....9bd218376030cbce8b416dcd29a775c3