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Metronidazole-induced encephalopathy caused by hyperbaric oxygen therapy in a patient with mandibular osteomyelitis
- Source :
- Journal of Infection and Chemotherapy. 25:1057-1059
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Metronidazole (MNZ) is prescribed for the treatment of infection caused by anaerobic bacteria and protozoa. Metronidazole-induced encephalopathy (MIE) has been known to be a side-effect, although its onset ratio is unclear. However, to the best of our knowledge, MIE associated with hyperbaric oxygen therapy (HBO) has not been previously reported. Here, we present the case of a 68-year-old man with mandibular osteomyelitis who received metronidazole for 49 days and received five times HBO therapy. He visited our hospital for evaluation and treatment of peripheral neuropathy, speech disturbance, nausea, and disturbance of gait after 47 days of initiating metronidazole treatment. Brain magnetic resonance imaging revealed hyperintense lesions in the cerebellar dentate nuclei, which was consistent with MIE. The patient's ataxic symptoms improved in 15 days after the discontinuation of MNZ. This is the first report demonstrating case of MIE could be related with HBO, as far as we had searched.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
0301 basic medicine
Microbiology (medical)
Cerebellar Ataxia
Nausea
030106 microbiology
Encephalopathy
03 medical and health sciences
0302 clinical medicine
Metronidazole
medicine
Humans
Mandibular Diseases
Pharmacology (medical)
030212 general & internal medicine
Radiation Injuries
Aged
Hyperbaric Oxygenation
Squamous Cell Carcinoma of Head and Neck
business.industry
Osteomyelitis
Mandibular osteomyelitis
Chemoradiotherapy
Staphylococcal Infections
medicine.disease
Magnetic Resonance Imaging
Neoadjuvant Therapy
Anti-Bacterial Agents
Tongue Neoplasms
Discontinuation
Treatment Outcome
Infectious Diseases
Peripheral neuropathy
Cerebellar Nuclei
Anesthesia
Drug Therapy, Combination
Anaerobic bacteria
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 1341321X
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Infection and Chemotherapy
- Accession number :
- edsair.doi.dedup.....9bd036c2f93abadd86f2e4fc7992f906