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Point-of-Care Ultrasound as a Tool to Assess Wound Size and Tissue Regeneration after Skin Grafting
- Source :
- Ultrasound in medicine & biology, vol 47, iss 9
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Chronic wounds can be difficult to heal and are often accompanied by pain and discomfort. Multiple skin substitutes or cellularized/tissue-based skin products have been used in an attempt to facilitate closure of complex wounds. Allografts from cadaveric sources have been a viable option in achieving such closure. However, early assessment of graft incorporation has been difficult clinically, often with delayed evidence of failure. Visual cues to assess graft integrity have been limited and remain largely superficial at the skin surface. Furthermore, currently used optical imaging techniques can penetrate only a few millimeters deep into tissue. Ultrasound (US) imaging offers a potential solution to address this limitation. This work evaluates the use of US to monitor wound healing and allograft integration. We used a commercially available dual-mode (US and photoacoustic) scanner operating only in US mode. We compared the reported wound size from the clinic with the size measured using US in 45 patients. Two patients from this cohort received an allogenic skin graft and underwent multiple US scans over a 110-d period. All data were processed by two independent analysts; one of them was blinded to the study. We measured change in US intensity and wound contraction as a function of time. Our results revealed a strong correlation (R2=0.81, p < 0.0001) between clinically and US-measured wound sizes. Wound contraction >91% was seen in both patients after skin grafting. An inverse relationship between wound size and US intensity (R2=0.77, p < 0 .0001) indicated that the echogenicity of the wound bed increases as healthy cells infiltrate the allograft matrix, regenerating and leading to healthy tissue and re-epithelization. This work indicates that US can be used to measure wound size and visualize tissue regeneration during the healing process.
- Subjects :
- medicine.medical_specialty
Acoustics and Ultrasonics
medicine.medical_treatment
Point-of-Care Systems
Wound size
Clinical Sciences
Biophysics
Regenerative Medicine
Cellularized
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Clinical Research
Skin grafts
medicine
Humans
Radiology, Nuclear Medicine and imaging
Process (anatomy)
030304 developmental biology
Skin
Ultrasonography
0303 health sciences
Wound Healing
Transplantation
screening and diagnosis
integumentary system
Radiological and Ultrasound Technology
business.industry
Point of care ultrasound
Ultrasound
Echogenicity
Skin Transplantation
Acoustics
Cellularized/tissue-based skin products
Tissue regeneration and wound sizing
Surgery
4.1 Discovery and preclinical testing of markers and technologies
Detection
Chronic wound care
tissue-based skin products
Skin grafting
Biomedical Imaging
Point of care ultrasound imaging
Cadaveric spasm
business
Wound healing
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Ultrasound in medicine & biology, vol 47, iss 9
- Accession number :
- edsair.doi.dedup.....9bcacac304ce93ff525a9022e7b21542