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Venous Malformations in Childhood: Clinical, Histopathological and Genetics Update
- Source :
- Dermatopathology, Dermatopathology, Vol 8, Iss 50, Pp 477-493 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Our knowledge in vascular anomalies has grown tremendously in the past decade with the identification of key molecular pathways and genetic mutations that drive the development of vascular tumors and vascular malformations. This has led us to better understand the pathogenesis of vascular lesions, refine their diagnosis and update their classification while also exploring the opportunity for a targeted molecular treatment. This paper aims to provide an overview of venous malformations (VM) in childhood. Specific entities include common VMs, cutaneo-mucosal VM, blue rubber bleb nevus syndrome or Bean syndrome, glomuvenous malformation, cerebral cavernous malformation, familial intraosseous vascular malformation and verrucous venous malformation. The clinicopathological features and the molecular basis of each entity are reviewed.
- Subjects :
- Pathology
medicine.medical_specialty
business.industry
medicine.medical_treatment
Vascular malformation
somatic and germline mutations
Dermatology
Review
medicine.disease
targeted therapy
Blue rubber bleb nevus syndrome
Glomuvenous malformation
Targeted therapy
vascular anomalies
Vascular Tumors
venous malformations
RL1-803
histopathology
Medicine
Clinicopathological features
genetics
business
Venous malformation
Subjects
Details
- Language :
- English
- ISSN :
- 22963529
- Volume :
- 8
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Dermatopathology
- Accession number :
- edsair.doi.dedup.....9bcaa8e4acf24150f4f621d6321a8397