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Molecular and Radiological Features of Microsatellite Stable Colorectal Cancer Cases With Dramatic Responses to Immunotherapy
- Source :
- Anticancer Res, Anticancer research, vol 41, iss 6
- Publication Year :
- 2021
-
Abstract
- Background/aim The majority of colorectal cancer (CRC) cases, which are microsatellite stable (MSS) and do not harbor mismatch repair deficiency/microsatellite instability, are resistant to immunotherapy. Identification of patients with exceptional responses in MSS CRC and predictive biomarkers is an unmet need that needs to be addressed. Case report We report three cases of MSS CRC with durable clinical benefit from immunotherapy with anti-PD-1 checkpoint inhibitors. Two cases bear a POLE P286R mutation, which has been associated with lack of immunotherapy response in MSS CRC. Two cases bear alterations in Ataxia-Telangiectasia Mutated (ATM) which may contribute to observed responses, including interaction with a co-administered intratumoral stimulator of interferon genes (STING) pathway agonist in one patient. Conclusion Novel DNA damage repair alterations, including mutations in ATM, can provide insight into additional mechanisms by which genomic alterations can sensitize MSS CRC to diverse immunotherapies.
- Subjects :
- Male
Cancer Research
Colorectal cancer
medicine.medical_treatment
Ataxia Telangiectasia Mutated Proteins
Neurodegenerative
Injections, Intralesional
medicine.disease_cause
checkpoint inhibition
Antineoplastic Combined Chemotherapy Protocols
Medicine
Tomography
Cancer
Mutation
General Medicine
Middle Aged
X-Ray Computed
Intralesional
Colo-Rectal Cancer
Oncology
Stimulator of interferon genes
Female
Microsatellite Instability
Immunotherapy
Colorectal Neoplasms
Adult
DNA damage
Oncology and Carcinogenesis
colorectal cancer
Article
Injections
Vaccine Related
Ataxia Telangiectasia
Rare Diseases
Genetics
Humans
Oncology & Carcinogenesis
business.industry
Microsatellite instability
medicine.disease
digestive system diseases
Sting
Microsatellite Stable
Cancer research
Immunization
Digestive Diseases
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 17917530
- Volume :
- 41
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.doi.dedup.....9bc7209d398d382e2d086ab783cfe14f