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Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control
- Publication Year :
- 2007
-
Abstract
- Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable long-term non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P < 0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.
- Subjects :
- Immunology
HIV Infections
Immune control
Asymptomatic
HIV Long-Term Survivors
Immunopathology
Lymphopenia
medicine
Immunology and Allergy
Humans
Lymphocyte Count
Sida
Leukopenia
biology
business.industry
Interleukin-7
medicine.disease
biology.organism_classification
CD4 Lymphocyte Count
Infectious Diseases
HIV-1
Viral disease
Lymphocytopenia
medicine.symptom
business
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9bc246f82416cfc0787dfb20ef0fa53a