Significant elevation of free itraconazole concentration at onset of adverse effects: A case report

Authors :: Kenji Umeki
Yosuke Suzuki
Jun-ichi Kadota
Ryota Tanaka
Kazufumi Hiramatsu
Hiroki Itoh
Mari Yamasue
Ryosuke Tatsuta
Kazuhiko Hashinaga
Hiroyuki Matsumoto
Katsuhiko Kamei
Source :: Clinical Case Reports, Clinical Case Reports, Vol 9, Iss 3, Pp 1187-1192 (2021)
Publication Year :: 2021
Publisher :: John Wiley and Sons Inc., 2021.
Abstract: Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects.

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