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Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data
- Source :
- Analytical chemistry, 2020, Vol.92(16), pp.10881-10890 [Peer Reviewed Journal], Analytical chemistry, Analytical Chemistry, Analytical Chemistry, American Chemical Society, 2020, 92 (16), pp.10881-10890. ⟨10.1021/acs.analchem.9b05792⟩, Allison, T M, Barran, P, Benesch, J L P, Cianferani, S, Degiacomi, M T, Gabelica, V, Grandori, R, Marklund, E G, Menneteau, T, Migas, L G, Politis, A, Sharon, M, Sobott, F & Thalassinos, K 2020, ' Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data ', Analytical Chemistry, vol. 92, no. 16, pp. 10881-10890 . https://doi.org/10.1021/acs.analchem.9b05792
- Publication Year :
- 2020
-
Abstract
- The past few years have seen a dramatic increase in applications of native mass and ion mobility spectrometry, especially for the study of proteins and protein complexes. This increase has been catalyzed by the availability of commercial instrumentation capable of carrying out such analyses. As in most fields, however, the software to process the data generated from new instrumentation lags behind. Recently, a number of research groups have started addressing this by developing software, but further improvements are still required in order to realize the full potential of the data sets generated. In this perspective, we describe practical aspects as well as challenges in processing native mass spectrometry (MS) and ion mobility-MS data sets and provide a brief overview of currently available tools. We then set out our vision of future developments that would bring the community together and lead to the development of a common platform to expedite future computational developments, provide standardized processing approaches, and serve as a location for the deposition of data for this emerging field. This perspective has been written by members of the European Cooperation in Science and Technology Action on Native MS and Related Methods for Structural Biology (EU COST Action BM1403) as an introduction to the software tools available in this area. It is intended to serve as an overview for newcomers and to stimulate discussions in the community on further developments in this field, rather than being an in-depth review. Our complementary perspective (http://dx.doi.org/10.1021/acs.analchem.9b05791) focuses on computational approaches used in this field.
- Subjects :
- Process (engineering)
Chemistry
business.industry
Ion-mobility spectrometry
010401 analytical chemistry
Ion Mobility
010402 general chemistry
01 natural sciences
Data science
Field (computer science)
0104 chemical sciences
Analytical Chemistry
Lead (geology)
Software
[CHIM]Chemical Sciences
Instrumentation (computer programming)
Software requirements
Set (psychology)
business
ComputingMilieux_MISCELLANEOUS
Subjects
Details
- ISSN :
- 15206882 and 00032700
- Volume :
- 92
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Analytical chemistry
- Accession number :
- edsair.doi.dedup.....9bbfadd05375b4b68467935ac22876a1